Sickle cell anemia – Nitric oxide related genetic modifiers of hematological and biochemical parameters
نویسندگان
چکیده
منابع مشابه
Nitric oxide status in sickle cell anemia
In this issue of the Revista Brasileira de Hematologia e Hemoterapia, Elias et al.(1) show the negative correlation between nitrite serum levels and the concentration of fetal hemoglobin (Hb F) in adult patients with sickle cell anemia. Hb F is a predictor of good prognosis in sickle cell anemia suggesting that the nitrite concentration might be used as a biomarker of the disease prognosis(1). ...
متن کاملEvaluation of clinical, biochemical and hematological parameters in macrocytic anemia
After the introduction of the automated cell coulters, the incidence of detecting macrocytosis have increased and has varied from 1.7 to 3.6% in several reported series. 1-4 Detectable macrocytosis may not be present in peripheral smear in about 33% of cases with MCV >100fl. 1 Mild increase in MCV (MCV of 100 – 110fl) is particularly common and most often remains unexplained though it cannot be...
متن کاملGenetic modifiers of sickle cell disease.
Sickle cell disease is one of the best characterized human monogenic disorders. Complex genotype/phenotype correlations clearly demonstrate the interaction of multiple genetic and environmental factors. In the last 20 years, scientific research has applied genetic approaches to dissect some of these modifiers. This review highlights the more recent genetic association studies that have been app...
متن کاملHematological parameters in sickle cell anemia patients with and without priapism.
BACKGROUND Priapism was associated with certain hematological parameters in sickle cell anemia (SCA) patients in one report but not in another. We studied differences in haematological parameters between SCA patients with and without priapism. PATIENTS AND METHODS Eighteen patients with SCA who presented with acute priapism during the years 2001-2004 were compared with age- and sex-matched SC...
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ژورنال
عنوان ژورنال: Clinical Hemorheology and Microcirculation
سال: 2017
ISSN: 1386-0291,1875-8622
DOI: 10.3233/ch-168008